Possible Glutamine Side Effects and Drug Interactions
Are there any Glutamine side effects or drug interactions with Glutamine?
No significant side effects have been reported in glutamine studies. Glutamine has been around for more than 15 years and has proven to be safe among healthy people.
However, certain medicines may interact with glutamine. The list below includes the generic name of drugs (not the brand name under which it's sold) which may have beneficial or adverse reactions when combined with glutamine.
The drug interactions are denoted as:
Glutamine Side Effects - Drug Interactions:
- BENEFICIAL - this means that when glutamine interacts with the given drug it will increase the need for glutamine and perhaps help minimize the side effect of the drug (if side effect of drug exists).
- AVOID - this means the interaction is negative and glutamine use should be avoided until you speak with your physician or pharmacist.
- CHECK - this means the interaction is inconclusive and may require further explanation by either your physician or pharmacist.
- Chemotherapy - Beneficial
- Cisplatin - Beneficial
- Cyclophosphamide - Beneficial
- Docetaxel - Beneficial
- Fluorouracil - Beneficial
- Methotrexate - Beneficial
- Paclitaxel - Beneficial
Glutamine Side Effects - Specific Warnings and Precautions
You may not be able to take Glutamine if you have certain conditions as outlined in the list below. Thus, precautions to be aware of concerning the safety of glutamine include the following:
- If you have severe liver disease such as liver failure, Glutamine supplementation may worsen (in theory) hepatic encephalopathy - a brain condition due to high ammonia levels caused by liver disease. This is due to the fact that the body breaks Glutamine down into ammonia.
Thus, if you have liver problems (especially severe liver disease), do not take Glutamine supplements without your healthcare provider's approval and regular supervision.
- If you have bipolar disorder (also known as manic depression) or suffer from seizures and epilepsy, Glutamine may increase the risk (in theory) of seizures, especially in people with a seizure disorder. In people with bipolar disorders it may increase the risk of mania.
If you have a history of seizures you need to check with your physician before you decide to take Glutamine. If you have bipolar disorder it's better to avoid taking Glutamine altogether.
- If you are allergic or sensitive to MSG (monosodium glutamate) you should avoid taking Glutamine. This is because Glutamine is chemically related to glutamate and because the body breaks down Glutamine into glutamate.
Thus, some people who are allergic or sensitive to MSG may also be allergic to glutamate.
- If you are pregnant or breastfeeding or thinking of becoming pregnant it is probably best to avoid taking Glutamine because it's not known whether Glutamine supplements are safe for pregnant or breastfeeding women.
Finally, if you decide to take Glutamine supplements (such as L-glutamine capsulesor L-Glutamine powder), what you see on the label may not reflect what is in the bottle.
Make sure the manufacturer of the L-glutamine product is a trusted and reputable manufacturer like Muscletech, NOW, Optimum Nutrition, EAS, Universal Nutrition, BSN, TwinLab, Ultimate Nutrition.
These companies abide by the rules of Good Manufacturing Practices (GMP) for drugs.
Other, less reputable brands/companies have been known to have had contaminated supplements containing heavy metals or even prescription drugs. Also, some have been found to have much more (or much less) of the featured ingredient than their label stated.
Thus, stick with the big trusted names.
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